Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY2 | P41231 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 2/20 | 0.31 |
| ▸ | DDO | Q99489 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7488455 | 0.92 | ATAD2 (0.40) | P2RY2POLBLMNAALDH1A1KDM4E | |
| SCHEMBL7840803 | 0.86 | ATAD2 (0.38) | P2RY2POLBLMNAALDH1A1KDM4E | |
| SCHEMBL7840949 | 0.83 | P2RY2 (0.39) | P2RY2POLBLMNAALDH1A1KDM4E | |
| SCHEMBL7490690 | 0.83 | P2RY2 (0.40) | P2RY2POLBLMNAALDH1A1KDM4E | |
| SCHEMBL7841473 | 0.82 | LMNA (0.37) | P2RY2POLBLMNAALDH1A1KDM4E | |
| SCHEMBL7841890 | 0.81 | LMNA (0.36) | P2RY2POLBLMNAALDH1A1KDM4E | |
| SCHEMBL7503494 | 0.79 | LMNA (0.33) | P2RY2POLBLMNAALDH1A1KDM4E | |
| SCHEMBL7495877 | 0.79 | P2RY2 (0.46) | P2RY2POLBLMNAALDH1A1KDM4E | |
| SCHEMBL7831877 | 0.79 | KMT2A (0.39) | P2RY2POLBLMNAALDH1A1TSHR | |
| SCHEMBL7489122 | 0.78 | CA12 (0.36) | P2RY2POLBLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996617-B1 | 2,4-Dithi(oxo)-pyridin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists | ASTRAZENECA AB (SE) | 2002-01-09 | — | — | EP | disclosed |
| US-6107297-A | 2,4-Dithi(oxo)-pyrimidin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-08-22 | — | — | US | disclosed |