Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.36 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | CA9 | Q16790 | 4/20 | 0.36 |
| ▸ | P2RY2 | P41231 | 4/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7488455 | 0.84 | ATAD2 (0.40) | P2RY2LMNAALDH1A1POLB | |
| SCHEMBL7507386 | 0.84 | CA12 (0.36) | CA12CA1CA9 | |
| SCHEMBL7840803 | 0.81 | ATAD2 (0.38) | P2RY2LMNAALDH1A1POLB | |
| SCHEMBL7486706 | 0.78 | P2RY2 (0.37) | P2RY2LMNAALDH1A1POLB | |
| SCHEMBL7490690 | 0.76 | P2RY2 (0.40) | P2RY2LMNAALDH1A1POLB | |
| SCHEMBL7841473 | 0.75 | LMNA (0.37) | P2RY2LMNAALDH1A1POLB | |
| SCHEMBL7503494 | 0.74 | LMNA (0.33) | P2RY2LMNAALDH1A1POLB | |
| SCHEMBL7916092 | 0.74 | P2RY2 (0.34) | P2RY2LMNAALDH1A1POLB | |
| SCHEMBL7840949 | 0.74 | P2RY2 (0.39) | P2RY2LMNAALDH1A1POLB | |
| SCHEMBL7491391 | 0.74 | P2RY2 (0.39) | P2RY2LMNAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996617-B1 | 2,4-Dithi(oxo)-pyridin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists | ASTRAZENECA AB (SE) | 2002-01-09 | — | — | EP | disclosed |
| US-6107297-A | 2,4-Dithi(oxo)-pyrimidin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-08-22 | — | — | US | disclosed |