Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY2 | P41231 | 14/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | UBE2N | P61088 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485651 | 0.91 | P2RY2 (0.47) | P2RY2LMNAKDM4EALDH1A1MAPT | |
| SCHEMBL7504709 | 0.87 | P2RY2 (0.39) | P2RY2 | |
| SCHEMBL7488455 | 0.86 | ATAD2 (0.40) | P2RY2LMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL7507931 | 0.80 | P2RY2 (0.47) | P2RY2MAPT | |
| SCHEMBL7840803 | 0.80 | ATAD2 (0.38) | P2RY2LMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL7486706 | 0.79 | P2RY2 (0.37) | P2RY2LMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL7491592 | 0.78 | ALDH1A1 (0.45) | P2RY2LMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL7490690 | 0.77 | P2RY2 (0.40) | P2RY2LMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL7491074 | 0.77 | P2RY2 (0.34) | P2RY2LMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL7841473 | 0.76 | LMNA (0.37) | P2RY2LMNAPOLBUBE2NKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996617-B1 | 2,4-Dithi(oxo)-pyridin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists | ASTRAZENECA AB (SE) | 2002-01-09 | — | — | EP | disclosed |
| US-6107297-A | 2,4-Dithi(oxo)-pyrimidin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-08-22 | — | — | US | disclosed |
| EP-0996617-A1 | NOVEL COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 2000-05-03 | — | — | EP | disclosed |
| WO-1999002501-A1 | NOVEL COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-01-21 | — | — | WO | disclosed |