Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 10/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7996733 | 0.87 | MMP3 (0.49) | MMP3MAPTMEN1NPC1RAB9A | |
| SCHEMBL7990113 | 0.87 | MMP3 (0.61) | MMP3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL7990117 | 0.87 | MMP3 (0.61) | MMP3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL7991703 | 0.80 | MMP3 (0.43) | MMP3MAPTMEN1NPC1RAB9A | |
| SCHEMBL7398298 | 0.79 | MMP3 (1.00) | MMP3MEN1KMT2A | |
| SCHEMBL11646131 | 0.77 | MAPT (0.62) | MAPTMEN1NPC1RAB9AKMT2A | |
| SCHEMBL7398557 | 0.73 | MMP3 (1.00) | MMP3MAPTSMPD1HDAC8HDAC6 | |
| SCHEMBL7993303 | 0.73 | MMP3 (0.64) | MMP3 | |
| SCHEMBL6391762 | 0.73 | MAPT (0.53) | MAPTNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL7389210 | 0.72 | MMP3 (0.90) | MMP3MAPTSMPD1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288261-B1 | DRUGS FOR INHIBITION OF ENZYMES | ABBOTT LABORATORIES | 2001-09-11 | — | — | US | claimed |
| US-6288261-B1 | DRUGS FOR INHIBITION OF ENZYMES | ABBOTT LABORATORIES | 2001-09-11 | — | — | US | disclosed |
| WO-2000037433-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 2000-06-29 | — | — | WO | disclosed |