SCHEMBL7487151

SCHEMBL7487151

O=C(Nc1ccc2[nH]ccc2c1)c1ccc(F)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 5/20 1.00
RAB9A P51151 5/20 1.00
ESR1 P03372 4/20 0.80
MAPT P10636 3/20 0.74
MAOA P21397 2/20 0.64
MAOB P27338 1/20 0.64
MEN1 O00255 1/20 0.56
KMT2A Q03164 1/20 0.56
PRKCI P41743 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30914582 0.91 NPC1 (0.84) NPC1RAB9AESR1MAPTMAOA
SCHEMBL29214224 0.91 NPC1 (0.84) NPC1RAB9AESR1MAPTMAOA
SCHEMBL18941215 0.86 NPC1 (0.75) NPC1RAB9AESR1MAPTMAOA
SCHEMBL18941235 0.86 NPC1 (0.75) NPC1RAB9AESR1MAPTMAOA
SCHEMBL4761937 0.85 NPC1 (1.00) NPC1RAB9AESR1MAPTMAOA
SCHEMBL31156451 0.85 NPC1 (1.00) NPC1RAB9AESR1MAPTMAOA
SCHEMBL13483892 0.83 NPC1 (0.71) NPC1RAB9AESR1MAPTMAOA
SCHEMBL1663482 0.83 NPC1 (0.71) NPC1RAB9AESR1MAPTMAOA
SCHEMBL28435041 0.83 NPC1 (0.74) NPC1RAB9AESR1MAPTMAOA
SCHEMBL3199345 0.83 NPC1 (0.74) NPC1RAB9AESR1MAPTMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116875475-A Yeast strain for high-yield cannabinoid synthesis precursor, construction method and application thereof 森瑞斯生物科技(深圳)有限公司 2023-10-13 CN claimed
CN-114171132-A Fatigue stress resistant absorbing layer mix proportion design method 北京工业大学 2022-03-11 CN claimed
US-20260084095-A1 Hydrophobic Alkyl-Ester Physical Solvents for CO2 Removal from H2 Produced from Synthesis Gas US ENERGY (US) 2026-03-26 US disclosed
EP-3784232-B1 IMPROVED METHODS FOR INDUCING TISSUE REGENERATION AND SENOLYSIS IN MAMMALIAN CELLS AGEX THERAPEUTICS INC (US) 2026-02-11 EP disclosed
EP-4676912-A2 COMPOUNDS, COMPOSITIONS, AND METHOD OF INHIBITING TAU PROTEIN AND ALPHA-SYNUCLEIN AGGREGATION Purdue Research Foundation (US) 2026-01-14 EP disclosed
US-20250340552-A1 COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISORDERS HOTSPOT THERAPEUTICS INC (US) 2025-11-06 US disclosed
EP-3977114-B1 ULTRASOUND SUB-SURFACE PROBE MICROSCOPY DEVICE AND CORRESPONDING METHOD TNO (NL) 2025-08-13 EP disclosed
CN-112955141-B Improved method for inducing tissue regeneration and senescent cell lysis in mammalian cells AGEX治疗公司 2025-02-14 CN disclosed
CN-114364265-B Flavanone derivatives and their use as sweetness enhancers 弗门尼舍有限公司 2025-01-03 CN disclosed
WO-2024251921-A1 ANTHRACYCLINES ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC (NL) 2024-12-12 WO disclosed
US-12130258-B2 Ultrasound sub-surface probe microscopy device and corresponding method NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) 2024-10-29 US disclosed
WO-1998046570-A1 SUBSTITUTED HETEROAROMATIC 5-HT1F AGONISTS ELI LILLY AND COMPANY (US) 1998-10-22 WO disclosed
CN-1184425-A 5-substituted-3- (1,2,3, 6-tetrahydropyridin-4-yl) -and 3- (piperidin-4-yl) -1H-indoles, 5-HT1FAgonists LILLY CO ELI (US) 1998-06-10 CN disclosed
EP-0832650-A2 Use of serotonin 5-HT1F agonists for the prevention of migraine ELI LILLY AND COMPANY (US) 1998-04-01 EP disclosed
WO-1998011895-A1 A METHOD FOR THE PREVENTION OF MIGRAINE ELI LILLY AND COMPANY (US) 1998-03-26 WO disclosed
EP-0824917-A2 Use of a serotonin 5-HTlf agonist in the manufacture of a medicament for treating or ameliorating the symptoms of common cold or allergic rhinitis ELI LILLY AND COMPANY (US) 1998-02-25 EP disclosed
WO-1998006402-A1 TREATMENT OF THE COMMON COLD OR ALLERGIC RHINITIS ELI LILLY AND COMPANY (US) 1998-02-19 WO disclosed
US-5708008-A TREATMENT OF MIGRAINE ELI LILLY AND COMPANY (US) 1998-01-13 US disclosed
WO-1996029075-A1 5-SUBSTITUTED-3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)- AND 3-(PIPERIDIN-4-YL)-1H-INDOLES: NEW 5-HT1F AGONISTS ELI LILLY AND COMPANY (US) 1996-09-26 WO disclosed
EP-0733628-A1 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists ELI LILLY AND COMPANY (US) 1996-09-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250340552-A1 COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISORDERS CYP27A1, PNLIP, GOT2 NPC1 51/4885RAB9A 2407/4885ESR1 1375/4885
US-20260084095-A1 Hydrophobic Alkyl-Ester Physical Solvents for CO2 Removal from H2 Produced from Synthesis Gas SCD, ELOVL3, ACAD10 NPC1 625/4885RAB9A 3921/4885ESR1 305/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.