Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7689241 | 0.82 | HCAR2 (0.48) | HPGDLMNAHSD17B10HCAR2ALPL | |
| SCHEMBL7481463 | 0.78 | HCAR2 (0.45) | HPGDLMNAHSD17B10HCAR2ALPL | |
| SCHEMBL7689472 | 0.77 | LMNA (0.47) | HPGDLMNAHSD17B10HCAR2TP53 | |
| SCHEMBL7681257 | 0.72 | SMN1; SMN2 (0.45) | HPGDLMNAHSD17B10HCAR2ALPL | |
| SCHEMBL7680997 | 0.71 | HTR2C (0.41) | HPGDLMNAHSD17B10HCAR2TP53 | |
| SCHEMBL7682852 | 0.70 | HSD17B10 (0.39) | HPGDLMNAHSD17B10HCAR2ALPL | |
| SCHEMBL7683237 | 0.70 | SMN1; SMN2 (0.48) | HPGDLMNAHCAR2TP53HTT | |
| SCHEMBL7683547 | 0.68 | MAP1LC3B (0.50) | LMNATP53HTTL3MBTL1MAP1LC3B | |
| SCHEMBL7683162 | 0.65 | HSP90AA1 (0.42) | — | |
| SCHEMBL426358 | 0.64 | HTR2C (0.52) | HPGDHSD17B10HCAR2TP53L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |