Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 3/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434831 | 0.80 | KMT2A (0.48) | TSHRDPP4MAPTKMT2ACYP3A4 | |
| SCHEMBL6765207 | 0.73 | CYP3A4 (0.45) | MAPTKMT2ACTSKKDM4ECYP3A4 | |
| SCHEMBL7427486 | 0.72 | MEN1 (0.47) | SMN1; SMN2DPP4KMT2ACTSKLMNA | |
| SCHEMBL7432035 | 0.71 | ALDH1A1 (0.48) | KMT2ACTSKCTSLCTSSMEN1 | |
| SCHEMBL7434825 | 0.70 | KMT2A (0.45) | MAPTKMT2ACTSKKDM4ECYP3A4 | |
| SCHEMBL5093139 | 0.70 | KMT2A (0.45) | MAPTKMT2ACTSKKDM4ECYP3A4 | |
| SCHEMBL5093142 | 0.69 | CTSK (0.47) | MAPTKMT2ACTSKCTSLCTSS | |
| SCHEMBL7431356 | 0.68 | KMT2A (0.46) | TSHRMAPTKMT2ACTSKCTSL | |
| SCHEMBL5099202 | 0.67 | KMT2A (0.43) | MAPTKMT2ACTSKKDM4ECYP3A4 | |
| SCHEMBL5092565 | 0.67 | CTSK (0.53) | KMT2ACTSKCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158986-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-27 | — | — | EP | claimed |
| EP-1158986-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-12-05 | — | — | EP | claimed |
| WO-2000038687-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | claimed |