Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427486 | 0.90 | MEN1 (0.47) | KMT2AALDH1A1MEN1GAADPP4 | |
| SCHEMBL7432035 | 0.85 | ALDH1A1 (0.48) | KMT2AALDH1A1MEN1EPHX2 | |
| SCHEMBL6765207 | 0.84 | CYP3A4 (0.45) | KMT2AMAPTCYP3A4CYP2C19TP53 | |
| SCHEMBL7434825 | 0.83 | KMT2A (0.45) | KMT2AMAPTCYP3A4CYP2C19TDP1 | |
| SCHEMBL5093139 | 0.83 | KMT2A (0.45) | KMT2AMAPTCYP3A4CYP2C19TDP1 | |
| SCHEMBL7431356 | 0.83 | KMT2A (0.46) | KMT2AMAPTTSHRALDH1A1MEN1 | |
| SCHEMBL5093142 | 0.83 | CTSK (0.47) | KMT2AMAPTCYP3A4CYP2C19TDP1 | |
| SCHEMBL7426883 | 0.82 | PAX8 (0.43) | MAPTTP53PKMALDH1A1NPSR1 | |
| SCHEMBL7427121 | 0.81 | MEN1 (0.55) | KMT2AMAPTCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL7487602 | 0.80 | ALOX15 (0.40) | KMT2AMAPTCYP3A4CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158986-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-27 | — | — | EP | claimed |
| EP-1158986-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-12-05 | — | — | EP | claimed |
| WO-2000038687-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | claimed |