Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434831 | 0.90 | KMT2A (0.48) | MEN1KMT2AGAADPP4ALDH1A1 | |
| SCHEMBL7431356 | 0.89 | KMT2A (0.46) | MEN1KMT2AGAALMNACTSK | |
| SCHEMBL4766701 | 0.83 | MEN1 (0.43) | MEN1KMT2AUSP2POLBGAA | |
| SCHEMBL7427478 | 0.83 | MEN1 (0.43) | MEN1KMT2AUSP2POLBGAA | |
| SCHEMBL7041672 | 0.83 | CTSK (0.47) | MEN1KMT2AUSP2GAACTSK | |
| SCHEMBL7426883 | 0.82 | PAX8 (0.43) | POLBGAALMNACTSKALDH1A1 | |
| SCHEMBL7432035 | 0.82 | ALDH1A1 (0.48) | MEN1KMT2ACTSKALDH1A1 | |
| SCHEMBL7427121 | 0.81 | MEN1 (0.55) | MEN1KMT2APOLBGAAALDH1A1 | |
| SCHEMBL4686330 | 0.80 | CTSK (0.60) | CTSK | |
| SCHEMBL7477927 | 0.79 | CTSK (0.50) | LMNACTSKSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158986-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-27 | — | — | EP | claimed |
| EP-1158986-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-12-05 | — | — | EP | claimed |
| WO-2000038687-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | claimed |