Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7751642 | 0.90 | MAPT (0.49) | MEN1KMT2AMAPTAPPADORA1 | |
| SCHEMBL7492350 | 0.89 | POLB (0.42) | MEN1KMT2APOLBMAPTAPP | |
| SCHEMBL7497413 | 0.87 | MAPT (0.42) | MAPTPTGDR2 | |
| SCHEMBL7494560 | 0.84 | LMNA (0.37) | MAPTKDM4EALDH1A1PTGDR2 | |
| SCHEMBL7750405 | 0.83 | SMN1; SMN2 (0.45) | MEN1KMT2APOLBMAPTAPP | |
| SCHEMBL7497760 | 0.82 | KDM4E (0.38) | MAPTMAPK1KDM4E | |
| SCHEMBL7497068 | 0.76 | DHODH (0.46) | MAPTMAPK1KDM4EPTGDR2 | |
| SCHEMBL7750629 | 0.75 | TSPO (0.45) | MAPTMAPK1KDM4EALDH1A1PTGDR2 | |
| SCHEMBL7497415 | 0.72 | KDM4E (0.41) | MAPTMAPK1KDM4EALDH1A1PTGDR2 | |
| SCHEMBL7494156 | 0.72 | TSPO (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000063-B1 | 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | SANOFI SYNTHELABO (FR) | 2002-10-23 | — | — | EP | disclosed |