Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | APP | P05067 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7492350 | 0.90 | POLB (0.42) | SMN1; SMN2POLBKMT2AMAPTAPP | |
| SCHEMBL7751642 | 0.85 | MAPT (0.49) | KMT2AMAPTAPPALDH1A1KDM4E | |
| SCHEMBL7497068 | 0.84 | DHODH (0.46) | MAPTKDM4EL3MBTL1MAPK1 | |
| SCHEMBL7490382 | 0.83 | MEN1 (0.42) | POLBKMT2AMAPTAPPALDH1A1 | |
| SCHEMBL7750629 | 0.82 | TSPO (0.45) | MAPTALDH1A1KDM4EHSD17B10L3MBTL1 | |
| SCHEMBL7497415 | 0.80 | KDM4E (0.41) | MAPTALDH1A1KDM4EPDE4APDE4B | |
| SCHEMBL7494156 | 0.79 | TSPO (0.58) | — | |
| SCHEMBL7499843 | 0.77 | CYP1A2 (0.41) | CYP2C19CYP1A2MAPTKDM4EL3MBTL1 | |
| SCHEMBL7497413 | 0.76 | MAPT (0.42) | MAPT | |
| SCHEMBL7750489 | 0.75 | TP53 (0.53) | POLBKMT2AMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262045-B1 | TREATMENT OF ANXIETY; SLEEP DISORDER; EPILEPSY; SPASTICITY; MUSCLE CONTRACTURE OR AN EXTRAPYRAMIDAL SYNDROM; INDUCING OR MAINTAINING ANAESTHESIA | SANOFI-SYNTHELABO (FR) | 2001-07-17 | — | — | US | disclosed |