Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7494156 | 0.90 | TSPO (0.58) | TSPO | |
| SCHEMBL7497068 | 0.90 | DHODH (0.46) | TSPOMAPTPTGDR2DHODHKDM4E | |
| SCHEMBL7497415 | 0.88 | KDM4E (0.41) | TSPOMAPTPTGDR2DHODHKDM4E | |
| SCHEMBL7492350 | 0.85 | POLB (0.42) | MAPTPTGDR2KDM4EMAPK1L3MBTL1 | |
| SCHEMBL7499843 | 0.85 | CYP1A2 (0.41) | TSPOMAPTDHODHKDM4EMAPK1 | |
| SCHEMBL7750405 | 0.82 | SMN1; SMN2 (0.45) | MAPTKDM4EMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL7497413 | 0.80 | MAPT (0.42) | TSPOMAPTPTGDR2DHODH | |
| SCHEMBL7494560 | 0.77 | LMNA (0.37) | TSPOMAPTPTGDR2KDM4EALDH1A1 | |
| SCHEMBL7750388 | 0.76 | TSPO (0.56) | TSPOMAPTKDM4EMAPK1ALDH1A1 | |
| SCHEMBL7750398 | 0.75 | TSPO (0.69) | TSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262045-B1 | TREATMENT OF ANXIETY; SLEEP DISORDER; EPILEPSY; SPASTICITY; MUSCLE CONTRACTURE OR AN EXTRAPYRAMIDAL SYNDROM; INDUCING OR MAINTAINING ANAESTHESIA | SANOFI-SYNTHELABO (FR) | 2001-07-17 | — | — | US | disclosed |