Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL7483217 | 0.79 | OPRM1 (0.48) | OPRM1OPRK1OPRL1DRD2HTR7 | |
| SCHEMBL7485563 | 0.78 | HTR1D (0.57) | OPRM1OPRK1OPRL1HTR1A | |
| SCHEMBL7533736 | 0.77 | CYP1A2 (0.62) | OPRM1OPRK1OPRL1SLC6A4ADRA1D | |
| SCHEMBL7487981 | 0.76 | CCR2 (0.49) | OPRM1OPRK1OPRL1SLC6A4DRD2 | |
| SCHEMBL7480617 | 0.76 | CCR2 (0.61) | DRD2CCR2 | |
| SCHEMBL7533678 | 0.76 | CYP1A2 (0.61) | OPRM1OPRK1OPRL1SLC6A4ADRA1D | |
| SCHEMBL30908884 | 0.76 | HTR1A (0.52) | OPRM1OPRK1OPRL1SLC6A4DRD2 | |
| SCHEMBL7483363 | 0.76 | HTR1A (0.52) | OPRM1OPRK1OPRL1SLC6A4DRD2 | |
| Hydrochloric Acid SCHEMBL9031725 | 0.76 | OPRM1 (0.59) | OPRM1OPRK1OPRL1SLC6A4HTR1A | |
| Hydrochloric Acid SCHEMBL9032172 | 0.75 | ADRA1D (0.74) | SLC6A4ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733628-B9 | 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1H-indoles: 5-HT1F agonists | LILLY CO ELI (US) | 2002-06-12 | — | — | EP | disclosed |
| EP-0733628-B1 | 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1H-indoles: 5-HT1F agonists | LILLY CO ELI (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5962474-A | ANALGESICS; HEADACHES | ELI LILLY AND COMPANY (US) | 1999-10-05 | — | — | US | disclosed |
| US-5708008-A | TREATMENT OF MIGRAINE | ELI LILLY AND COMPANY (US) | 1998-01-13 | — | — | US | disclosed |
| WO-1996029075-A1 | 5-SUBSTITUTED-3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)- AND 3-(PIPERIDIN-4-YL)-1H-INDOLES: NEW 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1996-09-26 | — | — | WO | disclosed |
| EP-0733628-A1 | 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists | ELI LILLY AND COMPANY (US) | 1996-09-25 | — | — | EP | disclosed |