SCHEMBL7533736

SCHEMBL7533736

Oc1ccc2[nH]cc(C3CCN(CCCc4ccccc4)CC3)c2c1

nearest known ligand 0.76

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.62
CYP3A4 P08684 1/20 0.62
CYP2D6 P10635 1/20 0.62
CYP2C9 P11712 1/20 0.62
THPO P40225 1/20 0.62
OPRM1 P35372 1/20 0.58
OPRK1 P41145 1/20 0.58
OPRL1 P41146 1/20 0.58
MAPT P10636 1/20 0.56
BLM P54132 1/20 0.56
NPSR1 Q6W5P4 1/20 0.56
ADRA1D P25100 4/20 0.56
SLC6A4 P31645 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7533678 0.97 CYP1A2 (0.61) CYP1A2CYP3A4CYP2D6CYP2C9THPO
Hydrochloric Acid SCHEMBL9031120 0.92 CYP1A2 (0.63) CYP1A2CYP3A4CYP2D6CYP2C9THPO
SCHEMBL8559411 0.87 HTR1A (0.61) CYP1A2CYP3A4CYP2D6CYP2C9THPO
SCHEMBL8554847 0.87 CYP1A2 (0.65) CYP1A2CYP3A4CYP2D6CYP2C9THPO
SCHEMBL7532398 0.86 OPRM1 (0.77) CYP1A2CYP3A4CYP2D6CYP2C9THPO
Hydrochloric Acid SCHEMBL9032172 0.85 ADRA1D (0.74) CYP2D6ADRA1DSLC6A4
SCHEMBL8556970 0.84 ADRA1D (0.60) CYP1A2CYP3A4CYP2D6CYP2C9THPO
SCHEMBL8559641 0.83 CYP1A2 (0.63) CYP1A2CYP3A4CYP2D6CYP2C9THPO
SCHEMBL7542348 0.83 CYP2D6 (0.62) CYP1A2CYP3A4CYP2D6CYP2C9THPO
SCHEMBL5705058 0.82 CYP1A2 (0.65) CYP1A2CYP3A4CYP2D6CYP2C9THPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1037635-A4 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2002-11-13 EP claimed
US-6476028-B1 Compounds and methods SMITHKLINE BEECHAM CORPORATION 2002-11-05 US claimed
EP-1037635-A1 COMPOUNDS AND METHODS Smithkline Beecham (US) 2000-09-27 EP claimed
WO-1999017773-A1 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 1999-04-15 WO claimed
EP-1037635-A4 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2002-11-13 EP disclosed
US-6476028-B1 Compounds and methods SMITHKLINE BEECHAM CORPORATION 2002-11-05 US disclosed
EP-1037635-A1 COMPOUNDS AND METHODS Smithkline Beecham (US) 2000-09-27 EP disclosed
WO-1999017773-A1 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 1999-04-15 WO disclosed