Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.45 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 11/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 11/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 11/20 | 0.49 |
| ▸ | HTR1A | P08908 | 6/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7491974 | 1.00 | ADRA1D (0.49) | ADRA1DADRA1AADRA1BHTR1AHTR7 | |
| Fumaric Acid SCHEMBL7493172 | 0.85 | HTR1A (0.53) | HTR1AHTR7DRD2DRD3 | |
| Fumaric Acid SCHEMBL7488619 | 0.85 | HTR1A (0.53) | HTR1AHTR7DRD2DRD3 | |
| Fumaric Acid SCHEMBL7491977 | 0.82 | DRD2 (0.45) | ADRA1DADRA1AADRA1BHTR1AHTR7 | |
| Fumaric Acid SCHEMBL7491971 | 0.82 | DRD2 (0.45) | ADRA1DADRA1AADRA1BHTR1AHTR7 | |
| SCHEMBL14761486 | 0.81 | DRD2 (0.60) | ADRA1DADRA1AADRA1BHTR1AHTR7 | |
| Fumaric Acid SCHEMBL7488585 | 0.80 | HRH3 (0.41) | HTR1AKDM4EALDH1A1TDP1DRD2 | |
| Fumaric Acid SCHEMBL7488578 | 0.80 | HRH3 (0.41) | HTR1AKDM4EALDH1A1TDP1DRD2 | |
| Fumaric Acid SCHEMBL7492264 | 0.79 | HRH3 (0.38) | HTR1AKDM4E | |
| Fumaric Acid SCHEMBL7492260 | 0.79 | HRH3 (0.38) | HTR1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023287-B1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PF MEDICAMENT (FR) | 2002-06-12 | — | — | EP | claimed |
| US-6303603-B1 | FOR THEARPY OF ANXIETY, DEPRESSION, SCHIZOPHRENIA | PIERRE FABRE MEDICAMENT (FR) | 2001-10-16 | — | — | US | claimed |
| EP-1023287-B1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PF MEDICAMENT (FR) | 2002-06-12 | — | — | EP | disclosed |
| US-6303603-B1 | FOR THEARPY OF ANXIETY, DEPRESSION, SCHIZOPHRENIA | PIERRE FABRE MEDICAMENT (FR) | 2001-10-16 | — | — | US | disclosed |