Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALPG | P10696 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7484704 | 0.86 | MAOB (0.45) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL7485681 | 0.85 | KDM4E (0.50) | KDM4EALDH1A1HSD17B10HPGDGLA | |
| SCHEMBL8183672 | 0.73 | HPGD (0.55) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL7484801 | 0.71 | RAB9A (0.42) | HPGDSMN1; SMN2HDAC1HTTKMT2A | |
| SCHEMBL7485171 | 0.70 | RAB9A (0.47) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL19000918 | 0.70 | KDM4E (0.68) | KDM4EALDH1A1HSD17B10HPGDGLA | |
| SCHEMBL7484551 | 0.69 | CCNC (0.36) | KDM4EALDH1A1HPGDHDAC1KMT2A | |
| SCHEMBL9229347 | 0.69 | KDM4E (0.60) | KDM4EALDH1A1HSD17B10HPGDGLA | |
| SCHEMBL6825155 | 0.69 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2HSP90AA1 | |
| SCHEMBL7493197 | 0.69 | MEN1 (0.43) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204644-A1 | SYNTHESIS OF SUBSTITUTED AMIDINES | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2000078725-A1 | SYNTHESIS OF SUBSTITUTED AMIDINES | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | disclosed |
| WO-2000078724-A2 | IMIDAZOLINDERIVATIVES THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | disclosed |