Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7501270 | 0.77 | HTR2A (0.57) | HTR2AHTR2CHTR2B | |
| SCHEMBL7499133 | 0.72 | HTR2A (0.62) | HTR2AHTR2CHTR2BPNMT | |
| SCHEMBL7493732 | 0.70 | HTR2C (0.64) | HTR2AHTR2CHTR2B | |
| Fumaric Acid SCHEMBL4830658 | 0.69 | LMNA (0.55) | HTR2AHTR2CHTR2B | |
| Fumaric Acid SCHEMBL7543324 | 0.69 | LMNA (0.55) | HTR2AHTR2CHTR2B | |
| SCHEMBL7495949 | 0.69 | HTR2A (0.40) | HTR2AHTR2B | |
| SCHEMBL19173231 | 0.68 | HTR7 (0.43) | HTR2AHTR2C | |
| SCHEMBL7501273 | 0.66 | — | — | |
| SCHEMBL6216648 | 0.63 | ALDH1A1 (0.72) | HTR2A | |
| SCHEMBL8888063 | 0.63 | HTR2C (0.65) | HTR2AHTR2CHTR2BPNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202964-A1 | CONDENSED INDOLINE DERIVATIVES AND THEIR USE AS 5HT, IN PARTICULAR 5HT2C, RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001012602-A1 | CONDENSED INDOLINE DERIVATIVES AND THEIR USE AS 5HT, IN PARTICULAR 5HT2C, RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2001-02-22 | — | — | WO | disclosed |