Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 5/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL748241 | 0.89 | LPAR1 (0.36) | ACHEKMT2ASRCBCHENPSR1 | |
| SCHEMBL745530 | 0.88 | HDAC1 (0.41) | ACHESIGMAR1MEN1KMT2ASRC | |
| SCHEMBL750133 | 0.88 | SRC (0.36) | ACHENR1I2LMNAADRA2ACYP2D6 | |
| SCHEMBL749530 | 0.86 | NR1I2 (0.45) | ACHENR1I2LMNAADRA2ACYP2D6 | |
| SCHEMBL747722 | 0.86 | ESRRG (0.41) | ACHELMNAHPGDSRCHDAC1 | |
| SCHEMBL750906 | 0.86 | TP53 (0.39) | LMNAMEN1KMT2ASRCHDAC1 | |
| SCHEMBL749993 | 0.85 | LPAR1 (0.39) | LMNAMEN1HPGDKMT2ASRC | |
| SCHEMBL751065 | 0.85 | SRC (0.38) | ACHELMNAMEN1HPGDKMT2A | |
| SCHEMBL746739 | 0.84 | SRC (0.37) | ACHELMNAHPGDSRCHDAC1 | |
| SCHEMBL747958 | 0.83 | TP53 (0.38) | LMNASIGMAR1MEN1KMT2ASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | claimed |