Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8836231 | 0.85 | TDO2 (0.45) | MAPK14TDO2MAPK13MAPK12MAPK11 | |
| SCHEMBL7495163 | 0.83 | TDO2 (0.43) | MAPK14TDO2IDO1RPS6KA3TGFBR1 | |
| SCHEMBL7496200 | 0.79 | MAPK14 (0.58) | MAPK14TDO2MAPK13MAPK12MAPK11 | |
| SCHEMBL6095042 | 0.78 | TDO2 (0.38) | MAPK14TDO2MAPK13MAPK12MAPK11 | |
| SCHEMBL4932513 | 0.76 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11S1PR1 | |
| SCHEMBL8836017 | 0.71 | TDO2 (0.54) | MAPK14TDO2GRM5TGFBR1 | |
| SCHEMBL3273312 | 0.70 | KMO (0.42) | MAPK14MAPK13MAPK12MAPK11IDO1 | |
| SCHEMBL30224316 | 0.70 | KMO (0.42) | MAPK14MAPK13MAPK12MAPK11IDO1 | |
| SCHEMBL8836756 | 0.70 | MAPK14 (0.50) | MAPK14TDO2MAPK13MAPK12MAPK11 | |
| SCHEMBL5256356 | 0.69 | TDO2 (0.54) | MAPK14TDO2RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686156-B1 | PYRAZOLITRIAZINES WITH INTERLEUKIN-1 AND TUMOUR NECROSIS FACTOR INHIBITORY ACTIVITY | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-07-17 | — | — | EP | disclosed |
| CN-1041929-C | Pyrazolitriazines with interleukin-1 and tumour necrosis factor inhibitory activity | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-02-03 | — | — | CN | disclosed |
| US-5670503-A | PROPHYLACTIC AND THERAPEUTIC TREATMENT OF INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR MEDIATED DISEASES SUCH AS INFLAMMATORY DISEASES, AUTOIMMUNE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-23 | — | — | US | disclosed |
| CN-1120840-A | Pyrazolitriazines with interleukin-1 and tumour necrosis factor inhibitory activity | FUJISAWA PHARAMCEUTICAL CO LTD (JP) | 1996-04-17 | — | — | CN | disclosed |
| EP-0686156-A1 | PYRAZOLITRIAZINES WITH INTERLEUKIN-1 AND TUMOUR NECROSIS FACTOR INHIBITORY ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-12-13 | — | — | EP | disclosed |
| WO-1994019350-A1 | PYRAZOLITRIAZINES WITH INTERLEUKIN-1 AND TUMOUR NECROSIS FACTOR INHIBITORY ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-01 | — | — | WO | disclosed |