Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8836231 | 0.80 | TDO2 (0.45) | TDO2MAPK14GRM5MAPK13MAPK12 | |
| SCHEMBL7495308 | 0.78 | MAPK14 (0.45) | TDO2MAPK14GRM5MAPK13MAPK12 | |
| SCHEMBL7495163 | 0.78 | TDO2 (0.43) | TDO2MAPK14CSNK1DCSNK1ECYP17A1 | |
| SCHEMBL7496200 | 0.73 | MAPK14 (0.58) | TDO2MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL24196283 | 0.66 | ALDH1A1 (0.47) | MEN1KMT2A | |
| SCHEMBL24196453 | 0.66 | HSD17B10 (0.45) | CYP2C9CYP2C19MEN1KMT2AGRM5 | |
| SCHEMBL8836017 | 0.66 | TDO2 (0.54) | TDO2MAPK14MEN1KMT2AGRM5 | |
| SCHEMBL1878087 | 0.66 | MAPK14 (0.48) | TDO2MAPK14CYP2C9CYP2C19MEN1 | |
| SCHEMBL20744375 | 0.66 | NLRP3 (0.41) | MAPK14MAPK13MAPK12MAPK11PDE10A | |
| SCHEMBL30684077 | 0.66 | NLRP3 (0.41) | MAPK14MAPK13MAPK12MAPK11PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060128759-A1 | Substituted isoxazole derivatives and their use in pharmaceutics | MERCKLE GMBH (DE) | 2006-06-15 | — | — | US | disclosed |
| EP-1530468-A1 | SUBSTITUTED ISOXAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS | MERCKLE GMBH (DE) | 2005-05-18 | — | — | EP | disclosed |
| WO-2004017968-A1 | SUBSTITUTED ISOXAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS | MERCKLE GMBH (DE) | 2004-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128759-A1 | Substituted isoxazole derivatives and their use in pharmaceutics | IFNG, IRF3, IL2 | TDO2 810/4885MAPK14 3157/4885CYP19A1 665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.