Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 3/20 | 0.49 |
| ▸ | PCSK9 | Q8NBP7 | 8/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.47 |
| ▸ | PGR | P06401 | 3/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | GUSB | P08236 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7489457 | 0.86 | AHR (0.49) | AHRPCSK9LOXL2GUSB | |
| SCHEMBL7492821 | 0.80 | PCSK9 (0.53) | AHRPCSK9LOXL2GUSB | |
| SCHEMBL7560407 | 0.77 | FLT3 (0.58) | AHRPCSK9LOXL2IDO1GUSB | |
| SCHEMBL19360302 | 0.75 | KDM4E (0.43) | PCSK9NR3C1PGRNR3C2 | |
| SCHEMBL30076020 | 0.75 | KDM4E (0.43) | PCSK9NR3C1PGRNR3C2 | |
| SCHEMBL6994522 | 0.74 | LOXL2 (0.53) | AHRPCSK9LOXL2GUSB | |
| SCHEMBL7491887 | 0.74 | PCSK9 (0.63) | AHRPCSK9LOXL2GUSB | |
| SCHEMBL28197849 | 0.73 | RORC (0.44) | NR3C1PGRNR3C2DHFRIDO1 | |
| SCHEMBL29403791 | 0.73 | LOXL2 (0.69) | AHRPCSK9LOXL2 | |
| SCHEMBL401081 | 0.73 | LOXL2 (0.69) | AHRPCSK9LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244652-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY | Cell Therapeutics Europe S.R.L. (IT) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047916-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2001-07-05 | — | — | WO | disclosed |