Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.49 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 2/20 | 0.48 |
| ▸ | CTSS | P25774 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.43 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL751179 | 0.86 | CTSL (0.55) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL15101058 | 0.85 | CTSL (0.50) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL749653 | 0.85 | ALDH1A1 (0.52) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL5206542 | 0.85 | CTSK (0.58) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL6471138 | 0.84 | CTSL (0.53) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL4313271 | 0.84 | FOLH1 (0.52) | SIRT2SIRT1CTSLCTSSCTSK | |
| SCHEMBL4313267 | 0.84 | FOLH1 (0.52) | SIRT2SIRT1CTSLCTSSCTSK | |
| SCHEMBL203729 | 0.83 | PPARA (0.49) | CTSLCTSSCTSK | |
| SCHEMBL14985678 | 0.83 | PPARA (0.49) | CTSLCTSSCTSK | |
| SCHEMBL2707957 | 0.83 | PPARA (0.49) | CTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430014-A1 | ANTIVIRAL COMPOUNDS | Gilead Sciences, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010132601-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2010-11-18 | — | — | WO | disclosed |