Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7498241 | 0.89 | KMT2A (0.39) | NR1H4KMT2ANPC1MEN1KCNK3 | |
| SCHEMBL7572346 | 0.84 | ITGB3 (0.50) | KMT2ANPC1MEN1KCNK3KCNK9 | |
| SCHEMBL8520753 | 0.83 | KMT2A (0.48) | NR1H4KMT2ANPC1MEN1KCNK3 | |
| SCHEMBL8296314 | 0.81 | ITGB3 (0.51) | KMT2APOLBALDH1A1MAPTITGB3 | |
| SCHEMBL7495912 | 0.81 | ITGB3 (0.51) | KMT2APOLBALDH1A1MAPTITGB3 | |
| SCHEMBL7495906 | 0.81 | ITGB3 (0.51) | KMT2APOLBALDH1A1MAPTITGB3 | |
| SCHEMBL7503257 | 0.80 | SMN1; SMN2 (0.42) | NR1H4KMT2ANPC1MEN1POLB | |
| SCHEMBL7503254 | 0.80 | SMN1; SMN2 (0.42) | NR1H4KMT2ANPC1MEN1POLB | |
| SCHEMBL8520757 | 0.72 | KMT2A (0.51) | NR1H4KMT2ANPC1MEN1KCNK3 | |
| SCHEMBL8520762 | 0.71 | KMT2A (0.44) | NR1H4KMT2ANPC1MEN1KCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894084-B1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2002-06-26 | — | — | EP | disclosed |
| EP-0894084-A1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-02-03 | — | — | EP | disclosed |
| WO-1997036860-A1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |