Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 4/20 | 0.45 |
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | PLG | P00747 | 2/20 | 0.45 |
| ▸ | PLAT | P00750 | 2/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.45 |
| ▸ | KLK1 | P06870 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8520925 | 0.90 | PLAU (0.49) | POLBITGB3ITGA2BPLAUPLG | |
| SCHEMBL7505503 | 0.85 | KMT2A (0.57) | KMT2APOLBMEN1NPC1ITGB3 | |
| SCHEMBL7505498 | 0.85 | KMT2A (0.57) | KMT2APOLBMEN1NPC1ITGB3 | |
| SCHEMBL7503148 | 0.84 | KMT2A (0.55) | KMT2APOLBMEN1NPC1ITGB3 | |
| SCHEMBL7503147 | 0.84 | KMT2A (0.55) | KMT2APOLBMEN1NPC1ITGB3 | |
| SCHEMBL7499925 | 0.83 | LMNA (0.47) | PARP1ROCK2HTTALDH1A1F10 | |
| SCHEMBL9303751 | 0.79 | ITGB3 (0.62) | KMT2APOLBMEN1ITGB3ITGA2B | |
| SCHEMBL8520753 | 0.79 | KMT2A (0.48) | KMT2APOLBMEN1NPC1ITGB3 | |
| SCHEMBL7506884 | 0.77 | ITGB3 (0.66) | KMT2APOLBNPC1ITGB3ITGA2B | |
| SCHEMBL7508818 | 0.77 | ITGB3 (0.66) | KMT2APOLBNPC1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894084-A1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-02-03 | — | — | EP | disclosed |
| WO-1997036860-A1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |