Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28405351 | 0.88 | TDP1 (0.44) | ALDH1A1POLBTDP1HSD17B10MEN1 | |
| SCHEMBL4375603 | 0.86 | ALDH1A1 (0.53) | ALDH1A1LMNAMAPK1CA1CA2 | |
| SCHEMBL10511751 | 0.85 | GPR35 (0.44) | ALDH1A1LMNAMAPK1TDP1HSD17B10 | |
| SCHEMBL14880715 | 0.82 | TSHR (0.48) | ALDH1A1LMNAPOLBTDP1ACHE | |
| SCHEMBL7007574 | 0.82 | TDP1 (0.35) | ALDH1A1LMNAMAPK1TDP1ACHE | |
| SCHEMBL11109664 | 0.79 | MAPT (0.40) | APPALDH1A1LMNAPOLBMAPK1 | |
| SCHEMBL7638079 | 0.78 | CYP19A1 (0.44) | APPALDH1A1LMNAPOLBMAPK1 | |
| SCHEMBL11287220 | 0.78 | APP (0.38) | APPALDH1A1LMNAPOLBMAPK1 | |
| SCHEMBL4669683 | 0.78 | AKR1C3 (0.40) | APPALDH1A1LMNAPOLBMAPK1 | |
| SCHEMBL1206907 | 0.75 | ALDH1A1 (0.53) | ALDH1A1MAPK1TDP1HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1905774-B1 | Fused heterocyclic compounds as serotonin receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2013-02-20 | — | — | EP | claimed |
| EP-1264826-A1 | NOVEL IMIDAZOLINE COMPOUNDS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2002-12-11 | — | — | EP | disclosed |
| EP-0740669-B1 | AZATRIOXASPIROALKENES AS PARASITICIDES | BAYER AG (DE) | 1999-04-28 | — | — | EP | disclosed |