Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.33 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.33 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499271 | 0.82 | APP (0.42) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL4375603 | 0.75 | ALDH1A1 (0.53) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL28405351 | 0.73 | TDP1 (0.44) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL14880715 | 0.72 | TSHR (0.48) | TDP1KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL1206907 | 0.71 | ALDH1A1 (0.53) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL9710324 | 0.71 | ALDH1A1 (0.48) | TDP1KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10511751 | 0.71 | GPR35 (0.44) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL27636988 | 0.71 | TDP1 (0.41) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL8374 | 0.69 | TDP1 (0.54) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL2193448 | 0.69 | TDP1 (0.45) | TDP1KMT2AMEN1GPR35ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1364953-A1 | TRIAZOLOQUINAZOLINE AND PYRAZOLOTRIAZOLOPYRIMIDINE DERIVATIVES, MEDICINAL COMPOSITIONS, ADENOSINE A3 RECEPTOR AFFINITY AGENTS, OCULAR TENSION LOWERING AGENTS, PREPARATIONS FOR PREVENTING AND TREATING GLAUCOMA AND METHOD OF LOWERING OCULAR TENSION | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2003-11-26 | — | — | EP | disclosed |