Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 9/20 | 0.43 |
| ▸ | CA2 | P00918 | 9/20 | 0.43 |
| ▸ | CA9 | Q16790 | 8/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA7 | P43166 | 2/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7498185 | 0.88 | PTGS2 (0.62) | PTGS1PTGS2 | |
| SCHEMBL7502762 | 0.87 | MAOA (0.48) | PTGS1PTGS2MAOACA1CA2 | |
| SCHEMBL7499610 | 0.85 | MAOA (0.46) | PTGS1PTGS2MAOACA1CA2 | |
| SCHEMBL7505272 | 0.84 | MEN1 (0.47) | PTGS1PTGS2MAOACA1CA2 | |
| SCHEMBL7496347 | 0.81 | MAOA (0.43) | PTGS1PTGS2MAOACA1CA2 | |
| SCHEMBL7501856 | 0.81 | LMNA (0.42) | PTGS1PTGS2CA1CA2CA9 | |
| SCHEMBL7499348 | 0.78 | PTGS2 (0.58) | PTGS1PTGS2 | |
| SCHEMBL7494744 | 0.78 | MAPT (0.40) | PTGS1PTGS2MAOACA1CA2 | |
| SCHEMBL806809 | 0.77 | LTA4H (0.47) | PTGS1PTGS2CA1CA2MAPT | |
| SCHEMBL7506276 | 0.75 | GAA (0.45) | PTGS1PTGS2CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966437-B1 | 5-AROYLNAPHTHALENE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2002-06-12 | — | — | EP | disclosed |
| US-6150397-A | 5-(PYRIDYL, FURYL, OR THIENYL SUBSTITUTED)-6-SUBSTITUTED-2--2-NAPHTHALENESULFONAMIDES OF GIVEN FORMULA; INHIBITORS OF PROSTAGLANDIN G/H SYNTHASE; TREATING INFLAMMATORY DISEASE SUCH AS GOUT, ARTHRITIS, MYOSITIS, SYNOVITIS | SYNTEX (U.S.A.) INC. (US) | 2000-11-21 | — | — | US | disclosed |
| EP-0966437-A1 | 5-AROYLNAPHTHALENE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1999-12-29 | — | — | EP | disclosed |
| US-5962531-A | PROSTAGLANDIN SYNTHASE INHIBITOR; RHEUMATIC DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1999-10-05 | — | — | US | disclosed |
| WO-1998032732-A1 | 5-AROYLNAPHTHALENE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-30 | — | — | WO | disclosed |