Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | TSPO | P30536 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | PER2 | O15055 | 2/20 | 0.36 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7497760 | 0.89 | KDM4E (0.38) | CYP1A2CYP2D6CYP2C19KDM4EMAPT | |
| SCHEMBL7497415 | 0.87 | KDM4E (0.41) | KDM4EMAPTMAPK1L3MBTL1DHODH | |
| SCHEMBL7497068 | 0.87 | DHODH (0.46) | KDM4EMAPTMAPK1L3MBTL1DHODH | |
| SCHEMBL7750629 | 0.85 | TSPO (0.45) | KDM4EMAPTMAPK1L3MBTL1DHODH | |
| SCHEMBL7494156 | 0.82 | TSPO (0.58) | TSPO | |
| SCHEMBL7492350 | 0.81 | POLB (0.42) | KDM4EMAPTMAPK1L3MBTL1 | |
| SCHEMBL7750405 | 0.77 | SMN1; SMN2 (0.45) | CYP1A2CYP2C19KDM4EMAPTMAPK1 | |
| SCHEMBL7497413 | 0.77 | MAPT (0.42) | MAPTDHODHPIK3R1PIK3CATSPO | |
| SCHEMBL7492444 | 0.76 | TSPO (0.46) | CYP1A2CYP2D6CYP2C19KDM4EMAPT | |
| SCHEMBL7494560 | 0.76 | LMNA (0.37) | KDM4EMAPTPIK3R1PIK3CAMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000063-B1 | 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | SANOFI SYNTHELABO (FR) | 2002-10-23 | — | — | EP | disclosed |
| US-6262045-B1 | TREATMENT OF ANXIETY; SLEEP DISORDER; EPILEPSY; SPASTICITY; MUSCLE CONTRACTURE OR AN EXTRAPYRAMIDAL SYNDROM; INDUCING OR MAINTAINING ANAESTHESIA | SANOFI-SYNTHELABO (FR) | 2001-07-17 | — | — | US | disclosed |