Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | IL1RN | P18510 | 2/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7507986 | 0.92 | HSD17B10 (0.41) | HSD17B10CTSBCA5ACTSK | |
| SCHEMBL7550435 | 0.85 | MEN1 (0.45) | NPC1RAB9AHSD17B10CTSK | |
| SCHEMBL7602074 | 0.84 | PPARA (0.45) | — | |
| SCHEMBL7546570 | 0.81 | MMP1 (0.39) | IL1RNERAP2ERAP1 | |
| SCHEMBL9503074 | 0.80 | HSD17B10 (0.47) | HSD17B10CTSBCTSK | |
| SCHEMBL9506271 | 0.80 | HSD17B10 (0.49) | HSD17B10CTSBCTSK | |
| SCHEMBL7505198 | 0.80 | HSD17B10 (0.49) | HSD17B10CTSBCTSK | |
| SCHEMBL7548309 | 0.76 | MMP1 (0.33) | IL1RNERAP2ERAP1 | |
| SCHEMBL7506441 | 0.72 | PPARA (0.47) | NPC1RAB9A | |
| SCHEMBL7500014 | 0.72 | HSD17B10 (0.50) | HSD17B10CTSBIL1RNERAP2ERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923585-B1 | PHOSPHINATE BASED INHIBITORS OF MATRIX METALLOPROTEASES | PFIZER (US) | 2002-05-08 | — | — | EP | disclosed |
| US-6147061-A | ANTIARTHRITIC AGENTS; ANTICANCER AGENTS; ORAL DISEASES | PFIZER INC. (US) | 2000-11-14 | — | — | US | disclosed |
| EP-0923585-A1 | PHOSPHINATE BASED INHIBITORS OF MATRIX METALLOPROTEASES | PFIZER INC. (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998003516-A1 | PHOSPHINATE BASED INHIBITORS OF MATRIX METALLOPROTEASES | PFIZER INC. (US) | 1998-01-29 | — | — | WO | disclosed |