Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7500022 | 0.92 | NPC1 (0.43) | HSD17B10CTSBCTSKCA5A | |
| SCHEMBL7546570 | 0.89 | MMP1 (0.39) | MMP1 | |
| SCHEMBL7550435 | 0.86 | MEN1 (0.45) | HSD17B10CTSKALDH1A1 | |
| SCHEMBL7602074 | 0.85 | PPARA (0.45) | — | |
| SCHEMBL7548309 | 0.83 | MMP1 (0.33) | MMP1 | |
| SCHEMBL9503074 | 0.81 | HSD17B10 (0.47) | HSD17B10CTSBCTSKALDH1A1CTSS | |
| SCHEMBL9506271 | 0.81 | HSD17B10 (0.49) | HSD17B10CTSBCTSKALDH1A1CTSS | |
| SCHEMBL7505198 | 0.81 | HSD17B10 (0.49) | HSD17B10CTSBCTSKALDH1A1CTSS | |
| SCHEMBL7506441 | 0.73 | PPARA (0.47) | ALDH1A1 | |
| SCHEMBL8048833 | 0.71 | HSD17B10 (0.52) | HSD17B10CTSBCTSKALDH1A1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923585-B1 | PHOSPHINATE BASED INHIBITORS OF MATRIX METALLOPROTEASES | PFIZER (US) | 2002-05-08 | — | — | EP | disclosed |
| US-6147061-A | ANTIARTHRITIC AGENTS; ANTICANCER AGENTS; ORAL DISEASES | PFIZER INC. (US) | 2000-11-14 | — | — | US | disclosed |
| EP-0923585-A1 | PHOSPHINATE BASED INHIBITORS OF MATRIX METALLOPROTEASES | PFIZER INC. (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998003516-A1 | PHOSPHINATE BASED INHIBITORS OF MATRIX METALLOPROTEASES | PFIZER INC. (US) | 1998-01-29 | — | — | WO | disclosed |