Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CTSK | P43235 | 5/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7505198 | 1.00 | HSD17B10 (0.49) | HSD17B10CTSBALDH1A1CTSKCTSS | |
| SCHEMBL9503074 | 0.86 | HSD17B10 (0.47) | HSD17B10CTSBALDH1A1CTSKCTSS | |
| SCHEMBL8064106 | 0.84 | ALDH1A1 (0.45) | ALDH1A1CTSKCTSSCTSL | |
| SCHEMBL8048833 | 0.81 | HSD17B10 (0.52) | HSD17B10CTSBALDH1A1CTSKCTSS | |
| SCHEMBL7355706 | 0.81 | HSD17B10 (0.52) | HSD17B10CTSBALDH1A1CTSKCTSS | |
| SCHEMBL7507986 | 0.81 | HSD17B10 (0.41) | HSD17B10CTSBALDH1A1CTSKCTSS | |
| SCHEMBL7500022 | 0.80 | NPC1 (0.43) | HSD17B10CTSBCTSK | |
| SCHEMBL27556472 | 0.79 | SLC15A1 (0.58) | HSD17B10CTSBALDH1A1CTSKCTSS | |
| SCHEMBL27556474 | 0.79 | SLC15A1 (0.58) | HSD17B10CTSBALDH1A1CTSKCTSS | |
| SCHEMBL7048219 | 0.79 | ALDH1A1 (0.47) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276436-B1 | PHOSPHINIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-16 | — | — | EP | disclosed |
| US-5006651-A | Rheumatic diseases, bone disorders | HOFFMAN-LA ROCHE INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4885283-A | Phosphinic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1989-12-05 | — | — | US | disclosed |