Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ASF1A | Q9Y294 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7550435 | 0.89 | MEN1 (0.45) | PPARAMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL7546570 | 0.83 | MMP1 (0.39) | PPARA | |
| SCHEMBL7507986 | 0.73 | HSD17B10 (0.41) | ALDH1A1 | |
| SCHEMBL7500022 | 0.72 | NPC1 (0.43) | NPC1RAB9A | |
| SCHEMBL7506431 | 0.72 | NPC1 (0.45) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL9372689 | 0.70 | NPC1 (0.60) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL7625201 | 0.69 | CPA3 (0.54) | SMN1; SMN2 | |
| SCHEMBL4173457 | 0.69 | TRPV1 (0.72) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL8185226 | 0.69 | MEN1 (0.62) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL7539973 | 0.68 | GRIA4 (0.54) | MEN1KMT2ASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923585-B1 | PHOSPHINATE BASED INHIBITORS OF MATRIX METALLOPROTEASES | PFIZER (US) | 2002-05-08 | — | — | EP | disclosed |
| US-6147061-A | ANTIARTHRITIC AGENTS; ANTICANCER AGENTS; ORAL DISEASES | PFIZER INC. (US) | 2000-11-14 | — | — | US | disclosed |
| EP-0923585-A1 | PHOSPHINATE BASED INHIBITORS OF MATRIX METALLOPROTEASES | PFIZER INC. (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998003516-A1 | PHOSPHINATE BASED INHIBITORS OF MATRIX METALLOPROTEASES | PFIZER INC. (US) | 1998-01-29 | — | — | WO | disclosed |