Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 6/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.39 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | PTGES | O14684 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | IL1RN | P18510 | 2/20 | 0.37 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.37 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.37 |
| ▸ | MMP13 | P45452 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7507986 | 0.89 | HSD17B10 (0.41) | MMP1 | |
| SCHEMBL7506441 | 0.83 | PPARA (0.47) | PPARA | |
| SCHEMBL7548309 | 0.82 | MMP1 (0.33) | MMP1IL1RNERAP2ERAP1MMP13 | |
| SCHEMBL7500022 | 0.81 | NPC1 (0.43) | IL1RNERAP2ERAP1 | |
| SCHEMBL7625201 | 0.77 | CPA3 (0.54) | PPARGPTGESALOX5 | |
| SCHEMBL7550435 | 0.75 | MEN1 (0.45) | PPARA | |
| SCHEMBL7602074 | 0.74 | PPARA (0.45) | PPARGPPARA | |
| SCHEMBL9503061 | 0.71 | SLC1A3 (0.43) | ANPEPRNPEP | |
| SCHEMBL9503068 | 0.71 | SLC1A3 (0.43) | ANPEPRNPEP | |
| SCHEMBL28226603 | 0.71 | GRIK1 (0.55) | MMP1ANPEPRNPEPDNPEPIL1RN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923585-B1 | PHOSPHINATE BASED INHIBITORS OF MATRIX METALLOPROTEASES | PFIZER (US) | 2002-05-08 | — | — | EP | disclosed |
| US-6147061-A | ANTIARTHRITIC AGENTS; ANTICANCER AGENTS; ORAL DISEASES | PFIZER INC. (US) | 2000-11-14 | — | — | US | disclosed |
| EP-0923585-A1 | PHOSPHINATE BASED INHIBITORS OF MATRIX METALLOPROTEASES | PFIZER INC. (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998003516-A1 | PHOSPHINATE BASED INHIBITORS OF MATRIX METALLOPROTEASES | PFIZER INC. (US) | 1998-01-29 | — | — | WO | disclosed |