SCHEMBL7500133

SCHEMBL7500133

c1ccc(CCc2cnoc2-c2ccc(CN3CCCCC3)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 10/20 0.48
CYP2D6 P10635 2/20 0.48
CYP2C19 P33261 1/20 0.48
HRH4 Q9H3N8 1/20 0.48
MCHR1 Q99705 1/20 0.43
MBTD1 Q05BQ5 1/20 0.42
L3MBTL3 Q96JM7 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
SIGMAR1 Q99720 1/20 0.42
KCNH2 Q12809 1/20 0.41
CHKA P35790 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7493959 0.76 HRH3 (0.48) HRH3CYP2D6CYP2C19HRH4MCHR1
SCHEMBL7500129 0.72 ACHE (0.46) SIGMAR1
SCHEMBL24023622 0.72 CYP2D6 (0.89) HRH3CYP2D6CYP2C19HRH4SIGMAR1
SCHEMBL1997330 0.72 CYP2D6 (0.89) HRH3CYP2D6CYP2C19HRH4SIGMAR1
SCHEMBL24023625 0.72 CYP2D6 (0.89) HRH3CYP2D6CYP2C19HRH4SIGMAR1
SCHEMBL11585348 0.72 SIGMAR1 (0.77) HRH3CYP2D6CYP2C19HRH4SIGMAR1
SCHEMBL8327 0.72 SIGMAR1 (0.77) HRH3CYP2D6CYP2C19HRH4SIGMAR1
SCHEMBL26532 0.72 SIGMAR1 (0.77) HRH3CYP2D6CYP2C19HRH4SIGMAR1
SCHEMBL11141692 0.72 SIGMAR1 (0.77) HRH3CYP2D6CYP2C19HRH4SIGMAR1
SCHEMBL688047 0.72 SIGMAR1 (0.77) HRH3CYP2D6CYP2C19HRH4SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1171122-A4 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO INC (US) 2002-05-29 EP disclosed
EP-1171122-A1 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Merck & Co., Inc. (US) 2002-01-16 EP disclosed
WO-2000059502-A1 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-10-12 WO disclosed