Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | DHPS | P49366 | 1/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.45 |
| ▸ | TUBB | P07437 | 1/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5746637 | 0.85 | DHPS (0.50) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL16125630 | 0.83 | HDAC1 (0.47) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL13545152 | 0.81 | TUBB4A (0.49) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL40257 | 0.80 | NAPRT (0.52) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL29684913 | 0.80 | NAPRT (0.52) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL30285461 | 0.79 | KEAP1 (0.50) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| Hydrochloric Acid SCHEMBL1374882 | 0.79 | KEAP1 (0.50) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL27341645 | 0.79 | HDAC1 (0.47) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL5891583 | 0.78 | DHPS (0.56) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL6518029 | 0.78 | ADAM17 (0.73) | ADAM17CTNNB1WNT3AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734386-B1 | PLATELET ACTIVATING FACTOR ANTAGONISTS: IMIDAZOPYRIDINE INDOLES | ABBOTT LAB (US) | 2002-02-06 | — | — | EP | disclosed |
| EP-0734386-A1 | PLATELET ACTIVATING FACTOR ANTAGONISTS: IMIDAZOPYRIDINE INDOLES | Abbott Laboratories (US) | 1996-10-02 | — | — | EP | disclosed |
| US-5486525-A | ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 1996-01-23 | — | — | US | disclosed |
| WO-1995016687-A1 | PLATELET ACTIVATING FACTOR ANTAGONISTS: IMIDAZOPYRIDINE INDOLES | ABBOTT LABORATORIES (US) | 1995-06-22 | — | — | WO | disclosed |