Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.55 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | CCR5 | P51681 | 1/20 | 0.49 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | PRCP | P42785 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9523607 | 0.91 | OPRM1 (0.56) | OPRM1OPRD1OPRK1OPRL1DRD2 | |
| SCHEMBL7402938 | 0.90 | OPRM1 (0.52) | OPRM1OPRD1OPRK1OPRL1DRD2 | |
| SCHEMBL9521516 | 0.88 | SLC18A3 (0.54) | OPRM1OPRD1OPRK1OPRL1DRD2 | |
| SCHEMBL10598753 | 0.80 | OPRM1 (0.63) | OPRM1OPRD1OPRK1OPRL1KCNH2 | |
| SCHEMBL7405479 | 0.79 | OPRK1 (0.52) | OPRM1OPRD1OPRK1OPRL1DRD2 | |
| SCHEMBL113896 | 0.79 | CYP1A2 (0.62) | OPRM1OPRD1OPRK1OPRL1KCNH2 | |
| SCHEMBL10601133 | 0.79 | CYP1A2 (0.62) | OPRM1OPRD1OPRK1OPRL1KCNH2 | |
| SCHEMBL7500754 | 0.78 | OPRM1 (0.51) | OPRM1OPRD1OPRK1OPRL1CARM1 | |
| SCHEMBL21000265 | 0.78 | DRD2 (0.53) | OPRM1DRD2CCR5SLC18A3DRD1 | |
| SCHEMBL12513620 | 0.78 | MC4R (0.65) | OPRM1OPRD1OPRK1OPRL1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0507863-A4 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | — | 1993-07-07 | — | — | EP | claimed |
| EP-0507863-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1992-10-14 | — | — | EP | claimed |
| WO-1991009594-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1991-07-11 | — | — | WO | claimed |