Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7501359 | 0.87 | ALDH1A1 (0.52) | KDM4ETHRBEPHX1SMN1; SMN2MEN1 | |
| SCHEMBL10789373 | 0.78 | TDP1 (0.58) | KDM4EMRGPRX1EPHX1SMN1; SMN2RAB9A | |
| SCHEMBL7789182 | 0.78 | LMNA (0.50) | SMN1; SMN2TSHR | |
| SCHEMBL2095920 | 0.77 | PLK1 (0.48) | TSHR | |
| SCHEMBL2095923 | 0.77 | PLK1 (0.50) | THRBMEN1GAAKMT2ATSHR | |
| SCHEMBL10889367 | 0.77 | ALDH1A1 (0.52) | KDM4EMRGPRX1EPHX1SMN1; SMN2MEN1 | |
| SCHEMBL7956543 | 0.77 | KMT2A (0.66) | KDM4ESMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL7495425 | 0.74 | FAAH (0.60) | KDM4ESMN1; SMN2GAAHPGDHTT | |
| SCHEMBL7956472 | 0.74 | GAA (0.71) | KDM4ESMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL7517447 | 0.74 | KMT2A (0.50) | THRBNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638075-B1 | THIAZOLE OR IMIDAZOLE DERIVATIVES AS MAILLARD REACTION INHIBITORS | OTSUKA PHARMA CO LTD (JP) | 2002-01-16 | — | — | EP | disclosed |
| WO-1998043649-A2 | AGE PRODUCTION INHIBITORY COMPOSITION COMPRISING A MAILLARD REACTION INHIBITOR AND VITAMIN B¿6? | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-10-08 | — | — | WO | disclosed |
| US-5677322-A | THERAPY FOR AGING, DIABETES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-10-14 | — | — | US | disclosed |