Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 1/20 | 0.40 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LONP1 | P36776 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7508066 | 0.92 | BCL2 (0.40) | SLC7A11MAPTESR1MAPK10KMT2A | |
| SCHEMBL7512877 | 0.88 | NR3C2 (0.45) | SLC7A11KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL11741106 | 0.86 | P2RX3 (0.44) | SLC7A11MAPTESR1MAPK10KMT2A | |
| SCHEMBL7508419 | 0.86 | ALDH1A1 (0.47) | KMT2AALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL754250 | 0.77 | EGLN1 (0.42) | KMT2AALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL27882116 | 0.76 | RNASEH1 (0.46) | MAPTESR1MAPK10KMT2AALDH1A1 | |
| SCHEMBL11747526 | 0.75 | P2RX3 (0.40) | MAPTESR1MAPK10KMT2AP2RX3 | |
| SCHEMBL11739215 | 0.75 | ALDH1A1 (0.50) | MAPTKMT2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL4806017 | 0.74 | FBP1 (0.43) | ALDH1A1 | |
| SCHEMBL11829444 | 0.73 | CES1 (0.45) | MAPTKDM4EALDH1A1HSD17B10RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042320-B1 | NEW COMPOUNDS WHICH ARE P2-PURINOCEPTOR 7-TRANSMEMBRANE (TM) G-PROTEIN COUPLED RECEPTOR ANTAGONISTS | ASTRAZENECA UK LTD (GB) | 2002-02-13 | — | — | EP | disclosed |
| US-6218376-B1 | FOR TREATING INFLAMMATORY DISEASES | ASTRAZENECA UK LIMITED (GB) | 2001-04-17 | — | — | US | disclosed |
| EP-1042320-A1 | NEW COMPOUNDS WHICH ARE P2-PURINOCEPTOR 7-TRANSMEMBRANE (TM) G-PROTEIN COUPLED RECEPTOR ANTAGONISTS | AstraZeneca UK Limited (GB) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999026944-A1 | NEW COMPOUNDS WHICH ARE P2-PURINOCEPTOR 7-TRANSMEMBRANE (TM) G-PROTEIN COUPLED RECEPTOR ANTAGONISTS | ASTRAZENEKA UK LIMITED (GB) | 1999-06-03 | — | — | WO | disclosed |