Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CETP | P11597 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7507291 | 0.73 | CETP (0.45) | KMT2AALDH1A1CETPLMNAHTT | |
| SCHEMBL6185816 | 0.70 | SYK (0.41) | POLBALDH1A1CETPLMNAL3MBTL1 | |
| SCHEMBL6186146 | 0.70 | PNMT (0.43) | ALDH1A1LMNATSHRHTTHSD17B10 | |
| SCHEMBL5201104 | 0.69 | EPHX1 (0.40) | POLBRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL29518423 | 0.66 | NOS3 (0.59) | ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL607015 | 0.66 | NOS3 (0.59) | ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL7559508 | 0.62 | CES2 (0.70) | POLBLMNATSHRHSD17B10 | |
| SCHEMBL4025014 | 0.60 | DDR1 (0.52) | RAB9AALDH1A1CETPTSHRSMN1; SMN2 | |
| SCHEMBL6921909 | 0.59 | POLB (0.63) | POLBRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL24852891 | 0.59 | NR3C2 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109803-A4 | SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO INC (US) | 2002-10-29 | — | — | EP | disclosed |
| EP-1109803-A1 | SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY | Merck & Co., Inc. (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000006563-A1 | SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO., INC. (US) | 2000-02-10 | — | — | WO | disclosed |