Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 1/20 | 0.35 |
| ▸ | P2RY2 | P41231 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7507165 | 0.82 | LMNA (0.34) | P2RY2LMNA | |
| SCHEMBL7488455 | 0.79 | ATAD2 (0.40) | P2RY2KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL7507329 | 0.78 | P2RY2 (0.41) | P2RY2KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL7490690 | 0.78 | P2RY2 (0.40) | P2RY2KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL7507735 | 0.77 | LMNA (0.38) | KDM4EALDH1A1HSD17B10TP53SMN1; SMN2 | |
| SCHEMBL7916092 | 0.76 | P2RY2 (0.34) | P2RY2KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL7503816 | 0.75 | P2RY2 (0.64) | P2RY2 | |
| SCHEMBL7506087 | 0.74 | P2RY2 (0.51) | P2RY2 | |
| SCHEMBL7506383 | 0.74 | P2RY2 (0.51) | GRM7P2RY2 | |
| SCHEMBL7840803 | 0.74 | ATAD2 (0.38) | P2RY2KDM4EMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042320-B1 | NEW COMPOUNDS WHICH ARE P2-PURINOCEPTOR 7-TRANSMEMBRANE (TM) G-PROTEIN COUPLED RECEPTOR ANTAGONISTS | ASTRAZENECA UK LTD (GB) | 2002-02-13 | — | — | EP | disclosed |
| US-6218376-B1 | FOR TREATING INFLAMMATORY DISEASES | ASTRAZENECA UK LIMITED (GB) | 2001-04-17 | — | — | US | disclosed |