Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7507735 | 0.85 | LMNA (0.38) | LMNABRD4 | |
| SCHEMBL7841237 | 0.83 | LMNA (0.42) | LMNABRD4 | |
| SCHEMBL7505786 | 0.82 | GRM7 (0.35) | LMNAP2RY2 | |
| SCHEMBL7507386 | 0.81 | CA12 (0.36) | — | |
| SCHEMBL7490690 | 0.80 | P2RY2 (0.40) | LMNABRD4P2RY2 | |
| SCHEMBL7509478 | 0.78 | LMNA (0.32) | LMNA | |
| SCHEMBL7492166 | 0.76 | LMNA (0.43) | LMNABRD4 | |
| SCHEMBL7509963 | 0.75 | P2RY2 (0.32) | P2RY2 | |
| SCHEMBL7508435 | 0.75 | P2RY2 (0.50) | P2RY2 | |
| SCHEMBL7916092 | 0.72 | P2RY2 (0.34) | LMNAP2RY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042320-B1 | NEW COMPOUNDS WHICH ARE P2-PURINOCEPTOR 7-TRANSMEMBRANE (TM) G-PROTEIN COUPLED RECEPTOR ANTAGONISTS | ASTRAZENECA UK LTD (GB) | 2002-02-13 | — | — | EP | disclosed |
| US-6218376-B1 | FOR TREATING INFLAMMATORY DISEASES | ASTRAZENECA UK LIMITED (GB) | 2001-04-17 | — | — | US | disclosed |