Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 7/20 | 0.44 |
| ▸ | GPR34 | Q9UPC5 | 3/20 | 0.42 |
| ▸ | MMEL1 | Q495T6 | 5/20 | 0.38 |
| ▸ | ACE | P12821 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | EMG1 | Q92979 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7507637 | 0.89 | MME (0.47) | MMEMMEL1ACE | |
| SCHEMBL7513252 | 0.84 | GPR34 (0.42) | MMEGPR34MMEL1ACEMEN1 | |
| SCHEMBL7507651 | 0.75 | PPARG (0.39) | MMEMMEL1MAPTECE1 | |
| SCHEMBL7508372 | 0.74 | ITGB1 (0.40) | MMEECE1 | |
| SCHEMBL1912592 | 0.72 | MMEL1 (0.46) | MMEMMEL1ECE1 | |
| SCHEMBL6125680 | 0.72 | MMEL1 (0.48) | MMEMMEL1ACE | |
| SCHEMBL3699639 | 0.72 | MMEL1 (0.48) | MMEMMEL1ACE | |
| SCHEMBL7536388 | 0.71 | CYP1A2 (0.42) | ECE1 | |
| SCHEMBL7541594 | 0.70 | GHSR (0.44) | MME | |
| SCHEMBL6128064 | 0.70 | MMP1 (0.48) | MMEL1MEN1MAPTKMT2AECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8877815-B2 | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP | NOVARTIS AG (CH) | 2014-11-04 | — | — | US | disclosed |
| US-8877815-B2 | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP | NOVARTIS AG (CH) | 2014-11-04 | — | — | US | disclosed |
| US-20120122764-A1 | SUBSTITUTED CARBAMOYLCYCLOALKYL ACETIC ACID DERIVATIVES AS NEP | NOVARTIS AG (CH) | 2012-05-17 | — | — | US | disclosed |
| US-20120122764-A1 | SUBSTITUTED CARBAMOYLCYCLOALKYL ACETIC ACID DERIVATIVES AS NEP | NOVARTIS AG (CH) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122764-A1 | SUBSTITUTED CARBAMOYLCYCLOALKYL ACETIC ACID DERIVATIVES AS NEP | MME, REN, ECE1 | MME 1/4885GPR34 1340/4885MMEL1 1000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.