Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.48 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.39 |
| ▸ | SDHB | P21912 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136177 | 0.86 | PTGS2 (0.44) | PTGS2PTGS1DGAT1 | |
| SCHEMBL7087803 | 0.77 | PTGS2 (0.45) | PTGS2PTGS1 | |
| SCHEMBL8802398 | 0.69 | ALOX5AP (0.38) | PTGS2PTGS1DGAT1 | |
| SCHEMBL16069684 | 0.68 | PTGS2 (0.36) | PTGS2PTGS1NR1H2NR1H3 | |
| SCHEMBL2148593 | 0.68 | CYP1A2 (0.43) | — | |
| SCHEMBL2315531 | 0.67 | DGAT1 (0.35) | DGAT1NR1H2NR1H3 | |
| SCHEMBL7087564 | 0.66 | MAPK14 (0.58) | PTGS2PTGS1SDHB | |
| SCHEMBL19952994 | 0.66 | PTGS2 (0.58) | PTGS2PTGS1SDHB | |
| SCHEMBL2148279 | 0.66 | PIN1 (0.41) | — | |
| SCHEMBL14701092 | 0.66 | PDE4D (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772601-B1 | 4,5-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2002-09-18 | — | — | EP | disclosed |
| US-6426360-B1 | ANTIARTHRITIC AGENTS | G D SEARLE & CO. | 2002-07-30 | — | — | US | disclosed |
| WO-1996003387-A1 | 4,5-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |