Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.37 |
| ▸ | GRK2 | P25098 | 4/20 | 0.37 |
| ▸ | PRKCA | P17252 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 2/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | GRK3 | P35626 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | F11 | P03951 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14690185 | 0.88 | MAPK14 (0.41) | MAPTMEN1KMT2ATEKF11 | |
| SCHEMBL14701090 | 0.87 | MAPK14 (0.43) | ROCK2GRK2PRKCAMEN1KMT2A | |
| SCHEMBL2148593 | 0.85 | CYP1A2 (0.43) | MAPTMEN1KMT2AMAPK14MAPK1 | |
| SCHEMBL16497609 | 0.82 | KDM4E (0.40) | MAPTMEN1KMT2ATEKF11 | |
| SCHEMBL16497631 | 0.81 | MEN1 (0.45) | PIN1MAPTMEN1KMT2ATEK | |
| SCHEMBL14690033 | 0.81 | DRD2 (0.38) | MAPTMEN1KMT2ATEKF11 | |
| SCHEMBL16497611 | 0.81 | RAF1 (0.48) | MAPTMEN1KMT2AF11MAPK14 | |
| SCHEMBL16497634 | 0.80 | ALOX5 (0.42) | MAPTMEN1KMT2ATEKF11 | |
| SCHEMBL2145931 | 0.80 | TEK (0.39) | MAPTMEN1KMT2ATEKF11 | |
| SCHEMBL16510872 | 0.78 | MEN1 (0.38) | MAPTMEN1KMT2ATEKF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130040983-A1 | RAF KINASE INHIBITORS | RUGA CORPORATION | 2013-02-14 | — | — | US | disclosed |
| WO-2011085269-A1 | RAF KINASE INHIBITORS | SELEXAGEN THERAPEUTICS, INC. (US) | 2011-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040983-A1 | RAF KINASE INHIBITORS | BRAF, RAF1, ARAF | PIN1 2829/4885MYC 368/4885PTGER4 3813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.