Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.64 |
| ▸ | HPGDS | O60760 | 3/20 | 0.56 |
| ▸ | CTSL | P07711 | 1/20 | 0.55 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.55 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.54 |
| ▸ | TACR1 | P25103 | 2/20 | 0.53 |
| ▸ | TYR | P14679 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.51 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.51 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.50 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7553966 | 0.92 | GPR132 (0.58) | ACEHPGDSLNPEPGPR132GAA | |
| SCHEMBL7703848 | 0.89 | GPR132 (0.63) | ACEHPGDSLNPEPGPR132TACR1 | |
| SCHEMBL7523142 | 0.88 | ACE (0.50) | ACEHPGDSCTSLLNPEPGPR132 | |
| SCHEMBL7709445 | 0.87 | ACE (0.70) | ACEHPGDSCTSLLNPEPGPR132 | |
| SCHEMBL7709356 | 0.85 | ACE (0.50) | ACEHPGDSLNPEP | |
| SCHEMBL7522184 | 0.84 | ATM (0.50) | ACELNPEPPOLBRAB9AMAPT | |
| SCHEMBL3936012 | 0.83 | ACE (0.72) | ACECTSLLNPEPGPR132TACR1 | |
| SCHEMBL3936009 | 0.83 | ACE (0.72) | ACECTSLLNPEPGPR132TACR1 | |
| SCHEMBL7709762 | 0.82 | ACE (0.47) | ACEHPGDSLNPEPGPR132TACR1 | |
| SCHEMBL5802843 | 0.81 | TYR (0.62) | CTSLTACR1TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362165-B1 | Hydroxyphenyl derivatives with HIV integrase inhibitory properties | PHARMACOR INC. (CA) | 2002-03-26 | — | — | US | disclosed |
| EP-1165492-A1 | HYDROXYPHENYL DERIVATIVES WITH HIV INTEGRASE INHIBITORY PROPERTIES | Pharmacor Inc. (CA) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059867-A1 | HYDROXYPHENYL DERIVATIVES WITH HIV INTEGRASE INHIBITORY PROPERTIES | PHARMACOR INC. (CA) | 2000-10-12 | — | — | WO | disclosed |