Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.50 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.48 |
| ▸ | HPGDS | O60760 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TERT | O14746 | 1/20 | 0.42 |
| ▸ | TOP1 | P11387 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.42 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7511099 | 0.88 | ACE (0.64) | ACELNPEPHPGDSCTSLGPR132 | |
| SCHEMBL7709356 | 0.83 | ACE (0.50) | ACELNPEPHPGDSERAP2ERAP1 | |
| SCHEMBL7522184 | 0.81 | ATM (0.50) | ACELNPEPAKR1B10TTRAKR1B1 | |
| SCHEMBL7553966 | 0.81 | GPR132 (0.58) | ACELNPEPHPGDSGPR132PPARG | |
| SCHEMBL7703848 | 0.80 | GPR132 (0.63) | ACELNPEPHPGDSGPR132TACR1 | |
| SCHEMBL7709762 | 0.80 | ACE (0.47) | ACELNPEPHPGDSGPR132AKR1B10 | |
| SCHEMBL19853660 | 0.76 | ACE (0.52) | ACECTSLFOLH1TACR1PPARA | |
| SCHEMBL3365762 | 0.76 | ACE (0.52) | ACECTSLFOLH1TACR1PPARA | |
| SCHEMBL12072102 | 0.76 | PIN1 (0.57) | GPR132FOLH1PPARGPPARA | |
| SCHEMBL12073397 | 0.76 | PIN1 (0.57) | GPR132FOLH1PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362165-B1 | Hydroxyphenyl derivatives with HIV integrase inhibitory properties | PHARMACOR INC. (CA) | 2002-03-26 | — | — | US | disclosed |
| EP-1165492-A1 | HYDROXYPHENYL DERIVATIVES WITH HIV INTEGRASE INHIBITORY PROPERTIES | Pharmacor Inc. (CA) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059867-A1 | HYDROXYPHENYL DERIVATIVES WITH HIV INTEGRASE INHIBITORY PROPERTIES | PHARMACOR INC. (CA) | 2000-10-12 | — | — | WO | disclosed |