Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.59 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.59 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.57 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.57 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.57 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.57 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.57 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.57 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.57 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.57 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8036286 | 0.89 | CHEK1 (0.67) | SLC22A6SLC22A8 | |
| SCHEMBL8034183 | 0.84 | CHEK1 (0.53) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8038375 | 0.83 | GRIA1 (0.46) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8038353 | 0.82 | GRIA1 (0.53) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL9056844 | 0.82 | SLC22A6 (0.53) | SLC22A6SLC22A8GRIK1GRIA1GRIA2 | |
| SCHEMBL7509983 | 0.79 | ADH5 (0.42) | — | |
| SCHEMBL6604714 | 0.79 | GRIA1 (0.66) | SLC22A6SLC22A8GRIK1GRIA1GRIA2 | |
| SCHEMBL8911643 | 0.78 | GRIK1 (0.65) | SLC22A6SLC22A8GRIK1GRIA1GRIA2 | |
| SCHEMBL8554054 | 0.76 | CHEK1 (0.52) | — | |
| SCHEMBL8558597 | 0.76 | CHEK1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743945-B1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 2002-03-06 | — | — | EP | disclosed |
| US-6121265-A | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 2000-09-19 | — | — | US | disclosed |
| US-5741785-A | IMIDAZOLO(1,2-A)QUINOXALINONE COMPOUNDS; ANTIISCHEMIC AGENTS; NERVOUS SYSTEM DISORDERS | NOVO NORDISK A/S (DK) | 1998-04-21 | — | — | US | disclosed |
| EP-0743945-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995021842-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1995-08-17 | — | — | WO | disclosed |