Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1483873 | 0.81 | SMN1; SMN2 (0.41) | GSK3AGSK3BMAPTNPC1CYP2C19 | |
| SCHEMBL7511370 | 0.81 | TAAR1 (0.42) | GSK3AGSK3BPDE10ANPC1CYP2C19 | |
| SCHEMBL1484114 | 0.70 | GSK3A (0.36) | GSK3AGSK3BMAPK14MGLLNPC1 | |
| SCHEMBL28310362 | 0.67 | GRM5 (0.45) | MAPK14NPC1CYP2C19POLBKDM4E | |
| SCHEMBL12830077 | 0.67 | GSK3A (0.36) | GSK3AGSK3BMGLLPOLBKDM4E | |
| SCHEMBL29738155 | 0.63 | ADORA2B (0.40) | MAPTNPC1CYP2C19KDM4EHPGD | |
| SCHEMBL17537368 | 0.61 | GSK3A (0.55) | GSK3AGSK3BMGLLPOLBKDM4E | |
| SCHEMBL29407807 | 0.61 | HPGD (0.48) | MAPTCYP2C19HPGDEP300CREBBP | |
| SCHEMBL11286754 | 0.58 | NOTUM (0.38) | MAPTNPC1POLBKDM4EHPGD | |
| SCHEMBL12660985 | 0.58 | MGLL (0.48) | GSK3AGSK3BMGLLPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001019800-A9 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | CURIS INC (US) | 2002-10-03 | — | — | WO | disclosed |
| EP-1216234-A2 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | Curis, Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001019800-A2 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | CURIS, INC. (US) | 2001-03-22 | — | — | WO | disclosed |