Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 3/20 | 0.57 |
| ▸ | THRB | P10828 | 3/20 | 0.57 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6655902 | 0.93 | THRB (0.51) | THRATHRBIDH1 | |
| SCHEMBL7516887 | 0.91 | THRA (0.58) | THRATHRBIDH1 | |
| SCHEMBL7514101 | 0.91 | THRB (0.60) | THRATHRBIDH1 | |
| SCHEMBL6660318 | 0.89 | THRA (0.66) | THRATHRB | |
| SCHEMBL7511685 | 0.89 | THRA (0.54) | THRATHRBIDH1 | |
| SCHEMBL6838046 | 0.89 | LMNA (0.48) | THRATHRBIDH1 | |
| SCHEMBL1642407 | 0.89 | THRA (0.58) | THRATHRB | |
| SCHEMBL7512547 | 0.87 | THRA (0.54) | THRATHRB | |
| SCHEMBL7519577 | 0.85 | THRA (0.54) | THRATHRB | |
| SCHEMBL14488938 | 0.85 | THRB (0.61) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002540189-A | — | — | 2002-11-26 | — | — | JP | claimed |
| US-20020107390-A1 | Thyromimetic organic compounds | KUKKOLA PAIVI J (US) | 2002-08-08 | — | — | US | claimed |
| WO-2002032408-A2 | COMBINATIONS OF A THYROMIMETIC COMPOUND AND A STATIN | NOVARTIS AG (CH) | 2002-04-25 | — | — | WO | claimed |
| US-20020045751-A1 | Thyromimetic organic compounds | NOVARTIS AG (CH) | 2002-04-18 | — | — | US | claimed |
| EP-1165502-A1 | DIARYL DERIVATIVES AND THEIR USE AS MEDICAMENTS | Novartis AG (CH) | 2002-01-02 | — | — | EP | claimed |
| WO-2000058279-A1 | DIARYL DERIVATIVES AND THEIR USE AS MEDICAMENTS | NOVARTIS AG (CH) | 2000-10-05 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020045751-A1 | Thyromimetic organic compounds | TPO, THRA, LPO | THRA 2/4885THRB 7/4885IDH1 4546/4885 |
| US-20020107390-A1 | Thyromimetic organic compounds | TSHR, NR1H3, NR1H2 | THRA 4/4885THRB 5/4885IDH1 3951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.