Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 5/20 | 0.36 |
| ▸ | HTR1D | P28221 | 4/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7515525 | 0.99 | HTR1A (0.46) | HTR1AMTNR1AMTNR1BHTR7ALDH1A1 | |
| Maleic Acid SCHEMBL7514854 | 0.92 | HTR1A (0.42) | HTR1AMTNR1AMTNR1BHTR7ALDH1A1 | |
| Fumaric Acid SCHEMBL7514859 | 0.92 | HTR1A (0.42) | HTR1AMTNR1AMTNR1BHTR7ALDH1A1 | |
| Succinic Acid SCHEMBL7517288 | 0.92 | HTR1A (0.45) | HTR1AMTNR1AMTNR1BHTR7ALDH1A1 | |
| Fumaric Acid SCHEMBL7515760 | 0.92 | HTR1A (0.42) | HTR1AMTNR1AMTNR1BHTR7ALDH1A1 | |
| Propionic Acid SCHEMBL7514987 | 0.91 | HTR1A (0.49) | HTR1AMTNR1AMTNR1BHTR7HTR1B | |
| SCHEMBL8891546 | 0.89 | HTR1A (0.47) | HTR1AMTNR1AMTNR1BHTR1BHTR1D | |
| SCHEMBL8892925 | 0.82 | HTR1A (0.41) | HTR1AMTNR1AMTNR1B | |
| SCHEMBL7519588 | 0.81 | MTNR1A (0.51) | HTR1AMTNR1AMTNR1BHTR7HTR1B | |
| SCHEMBL7510223 | 0.81 | HTR1A (0.58) | HTR1AMTNR1AMTNR1BHTR1BHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1166783-A2 | Tetrahydrobenz[CD]indole-6-carboxamides for treating sexual dysfunction | ELI LILLY AND COMPANY (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-0633023-A2 | Preventing emesis and treating sexual dysfunction using tetrahydrobenz CD indole-6-carboxamides | ELI LILLY AND COMPANY (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0285278-B1 | The use of tetrahydrobenz[C,D]indole-6-carboxamides for the preparation of a medicament for the treating anxiety | ELI LILLY AND COMPANY (US) | 1992-08-12 | — | — | EP | disclosed |
| EP-0285278-A2 | The use of tetrahydrobenz[C,D]indole-6-carboxamides for the preparation of a medicament for the treating anxiety | ELI LILLY AND COMPANY (US) | 1988-10-05 | — | — | EP | disclosed |
| US-4745126-A | Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides | ELI LILLY AND COMPANY (US) | 1988-05-17 | — | — | US | disclosed |